Aluminium lithium hydride → HCID 67302009, compound

HRID 1015369Notes

Reaction equation

HRID 1015369 reaction equation
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH:9]([O:12][C:13]2[C:18]([F:19])=[CH:17][CH:16]=[CH:15][C:14]=2[F:20])[CH2:8][CH2:7]1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[F:19][C:18]1[CH:17]=[CH:16][CH:15]=[C:14]([F:20])[C:13]=1[O:12][CH:9]1[CH2:10][CH2:11][CH:6]([CH2:4][OH:3])[CH2:7][CH2:8]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 67302000HCID 67302000, compound

Product 1

HCID 67302009HCID 67302009, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4-(2,6-Difluorophenoxy)cyclohexanecarboxylic acid ethyl ester (155 mg, 0.55 mmol) was carried out using Method H with lithium aluminum hydride (150 mg; 3.95 mmol) in tetrahydrofuran at 0° C. under nitrogen flow. Material was purified by flash chromatography using 2% methanol in dichloromethane to give 109 mgs of title compound. (82% yield).

Workup

  1. customat 0° C.
  2. customMaterial was purified by flash chromatography

Sources & evidence

ORD record
ord-40f9d963fe23497c9d657d438244351c
Source dataset
uspto-grants-2011_07
Patent number
US07985755B2

Reaction notes

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