Aluminium lithium hydride → HCID 67301499, compound

HRID 1015374Notes

Reaction equation

HRID 1015374 reaction equation
[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[CH2:4][CH:5]1[CH2:10][CH2:9][CH:8]([C:11](O)=[O:12])[CH2:7][CH2:6]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[CH2:4][CH:5]1[CH2:6][CH2:7][CH:8]([CH2:11][OH:12])[CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 67301422HCID 67301422, compound

Product 1

HCID 67301499HCID 67301499, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4-(2-Chlorobenzyl)cyclohexanecarboxylic acid (115 mg; 0.48 mmol) and lithium aluminum hydride (100 mg; 2.64 mmol) was carried out using Method H in 5 mL tetrahydrofuran. Material was purified by flash chromatography using 10-50% ethyl acetate in hexanes gradient to give 73 mgs of title compound. (67% yield).

Workup

  1. customMaterial was purified by flash chromatography

Sources & evidence

ORD record
ord-86dff50124044139a9601ed95ca478d1
Source dataset
uspto-grants-2011_07
Patent number
US07985755B2

Reaction notes

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