Hydrochloric Acid → HCID 10668521, compound

HRID 1016201Notes

Reaction equation

HRID 1016201 reaction equation
C(ON=O)CC(C)C.[I:9][C:10]1[CH:16]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:14]=[C:13]([I:21])[C:11]=1N.Cl>CN(C=O)C>[I:9][C:10]1[CH:16]=[C:15]([C:17]([F:20])([F:18])[F:19])[CH:14]=[C:13]([I:21])[CH:11]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8053Isoamyl NitriteHCID 106216472,6-diiodo-4-(trifluoromethyl)aniline

Product 1

HCID 10668521HCID 10668521, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a stirred solution of isopentylnitrite (365 mg, 3.12 mmol) in DMF (8 mL) at 65° C. was added 2,6-diiodo-4-(trifluoromethyl)aniline (685 mg, 1.66 mmol). The reaction was stirred overnight at rt then poured into 1 N HCl (10 mL) and extracted with methylene chloride. The organic layer was dried over sodium sulfate, filtered, concentrated and the residue was purified on silica (hexanes) to afford a pink solid.

Workup

  1. extractionextracted with methylene chloride
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customthe residue was purified on silica (hexanes)
  6. customto afford a pink solid

Sources & evidence

ORD record
ord-a3b4480479df498999dceb326f0c9d20
Source dataset
uspto-grants-2011_07
Patent number
US07985861B2

Reaction notes

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