Ethyl Acrylate → HCID 12021094, compound

HRID 1016302Notes

Reaction equation

HRID 1016302 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]2[NH:7][C:6]3[C:11]([C:15]#N)=[CH:12][N:13]=[CH:14][C:5]=3[C:4]=2[CH:3]=1.Cl[C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][C:22](CC#N)=[CH:21]2.C(OCC)(=[O:33])C=C>>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]2[N:7]3[C:6]4[C:11](=[CH:12][N:13]=[CH:14][C:5]=4[C:4]=2[CH:3]=1)[C:15](=[O:33])[C:19]([CH2:20][C:21]1[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=1)=[CH:18]3

Participants

4

Reactant 3

HCID 8821Ethyl AcrylateHCID 18406573HCID 18406573, compoundHCID 18406586HCID 18406586, compound

Product 1

HCID 12021094HCID 12021094, compoundYield 47%

Procedure

According to Example 5<step 1>, 8-chloro-4-cyano-5H-pyrido[4,3-b]indole (1.26 g) prepared from 5-chloro-2-cyanomethylindole by the procedure described in literature (Synthesis, 743 (1992) and Chem. Pharm. Bull., 29, 1280 (1981)) was reacted with ethyl acrylate (1.8 mL) to obtain the title compound (850 mg; 47%).

Workup

  1. customdescribed in literature (Synthesis, 743 (1992) and Chem. Pharm. Bull., 29, 1280 (1981))

Sources & evidence

ORD record
ord-7704628f8dca4e07a003191826c7ffa7
Source dataset
uspto-grants-2002_11
Patent number
US06476021B1

Reaction notes

Loading…