反应详情

A mixture of 5.4 g of 1,2-phenylenediamine and 4.5 g of dihydro-furan-2-one in 50 mL of 4N hydrochloric acid was heated to reflux for 20 h, 1 teaspoon of decolorizing carbon added, and after another 15 min reflux, filtered hot. The filtrate was concentrated under reduced pressure to near dryness, the residue made basic (pH=8) with saturated sodium bicarbonate and extracted into 3×80 mL of ether. The combined extracts were dried over magnesium sulfate and concentrated under reduced pressure. After drying under vacuum, 8.4 g of 3-(1H-benzimidazol-2-yl)-propan-1-ol was obtained as a solid.

1. temperaturewas heated
2. temperatureto reflux for 20 h
3. addition1 teaspoon of decolorizing carbon added
4. temperatureafter another 15 min reflux
5. filtrationfiltered hot
6. concentrationThe filtrate was concentrated under reduced pressure
7. extractionextracted into 3×80 mL of ether
8. dry with materialThe combined extracts were dried over magnesium sulfate
9. concentrationconcentrated under reduced pressure
10. customAfter drying under vacuum