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HRID1016489

反应详情

EQUATION

反应方程式

HRID 1016489 的结构方程式

REACTANTS

反应物

4
结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CCOP(=O)(OCC)On1nnc2ccccc2c1=O
HCID4293995

3-[(Diethoxyphosphoryl)oxy]-1,2,3-benzotriazin-4(3H)-one

C11H14N3O5P

结构：C[C@@H]1CN(C(=O)c2ccccc2)CCN1
HCID7578227

(R)-1-Benzoyl-3-methylpiperazine

C12H16N2O

结构：O=C([O-])C(=O)c1c[nH]c2ncccc12.[K+]
HCID23721194

Potassium oxo(1H-pyrrolo[2,3-b]pyridin-3-yl)acetate

C9H5KN2O3

PRODUCTS

生成物

1
结构：C[C@@H]1CN(C(=O)c2ccccc2)CCN1C(=O)C(=O)c1c[nH]c2ncccc12
HCID5495793

1-(4-Benzoyl-2-methylpiperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione

C21H20N4O3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Potassium 7-azaindole 3-glyoxylate 3a (25.4 g, 0.111 mol), (R)-3-methyl-N-benzoylpiperazine 4a (22.7 g, 0.111 mol), 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin4(3H)-one (DEPBT) (33.3 g, 0.111 mol) and Hunig's Base (28.6 g, 0.222 mol) were combined in 500 ml of DMF. The mixture was stirred at room temperature for 8 hours.