反应详情

温度

60 °C

A mixture of 2-methyl-5-benzothiazolol (8 g, 48.4 mmol), 1-bromo-3-chloropropane (23 g, 146 mmol), and potassium carbonate (33.6 g, 240 mmol) in 50 ml of acetonitrile was stirred at 60° C. for 18 hr. The mixture was cooled, evaporated under reduced pressure, diluted with water and ethyl acetate. The organic phase was separated, dried over sodium sulfate, and concentrated under vacuum to give 2-methyl-5-(3-chloropropoxyl)-benzothiazole (IV) as a tan crystalline solid (10 g, 85%, mp 63-65° C., MS (CI) m+1=242).

1. temperatureThe mixture was cooled
2. customevaporated under reduced pressure
3. additiondiluted with water and ethyl acetate
4. customThe organic phase was separated
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated under vacuum