Triethylamine → 1-Nonyl-3-(nonylamino)pyrrolidine-2,5-dione

HRID 1016518노트

반응식

HRID 1016518 반응식
[CH2:1]([N:10]1[C:14](=[O:15])[CH:13]=[CH:12][C:11]1=[O:16])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[CH2:17]([NH2:26])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25].C(N(CC)CC)C>C(#N)C>[CH2:1]([N:10]1[C:11](=[O:16])[CH2:12][CH:13]([NH:26][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[C:14]1=[O:15])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 16215NonylamineHCID 512831N-Nonylmaleimide

생성물 1

HCID 5128371-Nonyl-3-(nonylamino)pyrrolidine-2,5-dione

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of N-nonyl maleimide (0.01 M) prepared as described in Example 12 above, nonylamine (0.01 M), triethylamine [catalytic, 0.1 equivalent] in acetonitrile (25 ml) was stirred for 24 hours at room temperature. Acetonitrile was removed under vacuum to leave a residual liquid product which was flash chromatographed (25% ethyl acetate in petroleum ether) to yield a white solid as the desired product.

후처리

  1. customprepared
  2. customAcetonitrile was removed under vacuum
  3. customto leave a residual liquid product which
  4. customchromatographed (25% ethyl acetate in petroleum ether)

출처 및 근거

ORD 기록
ord-2aed532edae34e4cb59d532c90c4e534
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06476053B1

반응 노트

불러오는 중…