Water → Phenol, 5-chloro-2-methoxy-

HRID 1017243Notes

Reaction equation

HRID 1017243 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6](B(O)O)[CH:7]=1.[OH2:13]>OO.C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6]([OH:13])[CH:7]=1

Participants

5

Reactant 2

HCID 962WaterHCID 27357515-Chloro-2-methoxyphenylboronic acid

Product 1

HCID 588774Phenol, 5-chloro-2-methoxy-

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 784Hydrogen PeroxideSolvent

Procedure

A solution of 5-chloro-2-methoxy benzeneboronic acid (1.9 g, 10 mmol) in hydrogen peroxide (2.04 ml, 30% solution) and ethanol 40 ml was refluxed for 30 min. Water was added and the product was extracted with two portions of ethyiacetate. Drying over magnesium sulfate and evaporation of the solvent gave the product as an oil. Yield 1.05 g, 65%.

Workup

  1. extractionthe product was extracted with two portions of ethyiacetate
  2. dry with materialDrying over magnesium sulfate and evaporation of the solvent

Sources & evidence

ORD record
ord-318d396a9e96424597274760a712396d
Source dataset
uspto-grants-2002_11
Patent number
US06479491B1

Reaction notes

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