4-Methoxybenzaldehyde → 2-(4-Methoxyphenyl)quinazolin-4-ol

HRID 1017519Notes

Reaction equation

HRID 1017519 reaction equation
CO[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[NH:18][C:17](=[O:19])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1.[CH3:20][O:21]C1C=CC(C=O)=CC=1>>[CH3:20][O:21][C:7]1[CH:8]=[CH:3][C:4]([C:9]2[NH:18][C:17](=[O:19])[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=2)=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 312444-MethoxybenzaldehydeHCID 1354360052-(2-methoxyphenyl)-3H-quinazolin-4-one

Product 1

HCID 1354303092-(4-Methoxyphenyl)quinazolin-4-olYield 96.4%

Procedure

According to the preparation of 42, 4-methoxybenzaldehyde (35) (1.0 g, 7.3 mmol) was used to afford 44 (1.8 g, 96.4%) as pale yellow needles.

Sources & evidence

ORD record
ord-aa4eb513259940a098c471432112a1e8
Source dataset
uspto-grants-2002_11
Patent number
US06479499B1

Reaction notes

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