3-(3-Benzyl-3h-imidazol-4-yl)-1-(4-isobutylphenyl)-propen-1-one → 3-(3-Benzyl-3H-imidazol-4-yl)-5-isobutylindan-1-one

HRID 1017744Notes

Reaction equation

HRID 1017744 reaction equation
[CH2:1]([N:8]1[C:12]([CH:13]=[CH:14][C:15]([C:17]2[CH:22]=[CH:21][C:20]([CH2:23][CH:24]([CH3:26])[CH3:25])=[CH:19][CH:18]=2)=[O:16])=[CH:11][N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CS(O)(=O)=O>[CH2:1]([N:8]1[C:12]([CH:13]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([CH2:23][CH:24]([CH3:26])[CH3:25])[CH:21]=3)[C:15](=[O:16])[CH2:14]2)=[CH:11][N:10]=[CH:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 537079343-(3-Benzyl-3h-imidazol-4-yl)-1-(4-isobutylphenyl)-propen-1-one

Product 1

HCID 184052753-(3-Benzyl-3H-imidazol-4-yl)-5-isobutylindan-1-one

Reagents, catalysts & solvents 1

HCID 6395Methanesulfonic AcidSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 3-(3-benzyl-3H-imidazol-4-yl)-1-(4-isobutylphenyl)-propen-1-one (2.4 g) and methanesulfonic acid (40 ml) is heated at 120° C. for 40 minutes. Work-up of the reaction mixture gives the crude product, which is purified by flash chromatography by eluting with methylene chloride-methanol solution. The yield is 0.5 g.

Sources & evidence

ORD record
ord-272996a22c9f4bfbb521fd1fc634e1f2
Source dataset
uspto-grants-2002_11
Patent number
US06479530B2

Reaction notes

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