Hydrochloric Acid → HCID 178420016, compound

HRID 1017772Notes

Reaction equation

HRID 1017772 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[NH:18][N:17]=[N:16][N:15]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.C(Cl)(=O)C.Cl>CO>[NH:18]1[C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[N:15][N:16]=[N:17]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 18187701Tert-butyl 4-(2H-tetrazol-5-YL)piperidine-1-carboxylate

Product 1

HCID 178420016HCID 178420016, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To 100 mg of the solid from Step A was added a solution of 0.30 mL of acetyl chloride in 5 mL of methanol (generates a methanol solution of hydrochloric acid). After 2.5 hours at room temperature, the reaction was evaporated to dryness, triturated twice with ether and vacuum dried to give the title compound as a tan solid.

Workup

  1. customthe reaction was evaporated to dryness
  2. customtriturated twice with ether and vacuum
  3. customdried

Sources & evidence

ORD record
ord-dc82687e5d16495b92ddfd81be3a0600
Source dataset
uspto-grants-2002_11
Patent number
US06479518B2

Reaction notes

Loading…