反应详情

4.0 g (19.4 mmol) of ethyl 2-chloronicotinate, together with 3.2 g (19.4 mmol) of 1,2,3,4-tetrahydroisoquinoline hydrochloride and 5.36 g of potassium carbonate were heated at 110° C. for 3 h in 50 ml of DMF while stirring. Water was then added and the whole was extracted with ether; the ether phase was then washed with ammonium chloride, dried and evaporated. The crude product was purified chromatographically (silica gel/heptane-ethyl acetate 20-1), giving a yield of 4.8 g (87%).

1. extractionthe whole was extracted with ether
2. washthe ether phase was then washed with ammonium chloride
3. customdried
4. customevaporated
5. customThe crude product was purified chromatographically (silica gel/heptane-ethyl acetate 20-1)
6. customgiving a yield of 4.8 g (87%)