2,3-Dihydroxybutanedioic Acid → HCID 10856043, compound

Temperature

-20 °C

To a mixture of powder Molecular Sieves 4A (8.2 g), titanium tetraisopropoxide (5.1 ml) and methylene chloride (125 ml) was added dropwise diisopropyl L-(+)-tartrate (4.4 ml) under an argon stream at −20° C., followed by stirring under the same conditions for 30 minutes. Then, a methylene chloride solution (41 ml) of the compound obtained in the above (2) (13.9 g) was added and stirred at −20° C. for an hour. The mixture was cooled to −30° C., and tert-butyl hydroperoxide (3.2 M, methylene chloride solution, 48.3 ml) was added dropwise over 30 minutes. After the completion of the addition, stirring was continued at −20° C. for 18 hours, and dimethyl sulfide (14 ml) was added, followed by stirring at the same temperature for 3 hours. Then, an aqueous tartaric acid solution (10%, 9.3 ml) was added, successively followed by stirring at room temperature for an hour, addition of sodium fluoride (60 g), stirring for an hour, addition of Celite (34 g) and diethyl ether (96 ml), and stirring for an hour. Filtration and concentration gave an oily substance (41.9 g), which was then dissolved in diethyl ether (109 ml), and an aqueous sodium hydroxide solution (1N, 60 ml) was added, followed by stirring at room temperature for 1.5 hours. The organic layer was separated, the aqueous layer was extracted with diethyl ether, and the organic layers were combined, washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate and concentrated. The resulting residue was purified by a silica gel column chromatography (developing solvent; hexane:ethyl acetate=1:1) to give (2S,3S)-2,3-epoxy-5-phenyl-1-pentanol (14.2 g).

1. additionwas added
2. temperatureThe mixture was cooled to −30° C.
3. additionAfter the completion of the addition
4. stirringstirring
5. stirringby stirring at the same temperature for 3 hours
6. stirringby stirring at room temperature for an hour
7. stirringstirring for an hour
8. stirringstirring for an hour
9. filtrationFiltration and concentration
10. customgave an oily substance (41.9 g), which
11. stirringby stirring at room temperature for 1.5 hours
12. customThe organic layer was separated
13. extractionthe aqueous layer was extracted with diethyl ether
14. washwashed with a saturated aqueous sodium chloride solution
15. dry with materialdried over anhydrous magnesium sulfate
16. concentrationconcentrated
17. customThe resulting residue was purified by a silica gel column chromatography (developing solvent; hexane:ethyl acetate=1:1)

ORD record

ord-4d5da0aa9abf4215bb72b35ac144965b

Source dataset

uspto-grants-2002_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06482990B1