Propylamine → HCID 15895895, compound

HRID 1018908Notes

Reaction equation

HRID 1018908 reaction equation
[CH2:1]([O:3][P:4]([C:9]1[C:10](=[O:24])[NH:11][C:12]2[C:17]([CH:18]=1)=[CH:16][C:15]([S:19](Cl)(=[O:21])=[O:20])=[C:14]([Cl:23])[CH:13]=2)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2].[CH2:25]([NH2:28])[CH2:26][CH3:27]>C(#N)C.CCOCC>[CH2:1]([O:3][P:4]([C:9]1[C:10](=[O:24])[NH:11][C:12]2[C:17]([CH:18]=1)=[CH:16][C:15]([S:19]([NH:28][CH2:25][CH2:26][CH3:27])(=[O:21])=[O:20])=[C:14]([Cl:23])[CH:13]=2)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2]

Participants

5

Reactant 2

HCID 7852PropylamineHCID 88063986HCID 88063986, compound

Product 1

HCID 15895895HCID 15895895, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6342AcetonitrileSolvent

Procedure

A suspension of the compound obtained in Step E (1.26 g, 3.0 mmol) with n-propylamine (9.0 mmol) in 30 ml of acetonitrile is stirred for 3 hours. Evaporation to dryness is carried out, the residue is then taken up in 1N HCl and extraction is carried out with ethyl acetate. Drying over MgSO4 and evaporation of the organic phase yield a residue which is taken up in ether and filtered to yield the title product.

Workup

  1. customEvaporation to dryness
  2. extractionextraction
  3. dry with materialDrying over MgSO4 and evaporation of the organic phase
  4. customyield a residue which
  5. filtrationfiltered

Sources & evidence

ORD record
ord-e2114d3d9a534ca1905f0fa4c6a6beef
Source dataset
uspto-grants-2002_11
Patent number
US06486143B2

Reaction notes

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