反应详情

A mixture of 4-(4-fluorophenethyl)-3-methoxycarbonylbenzyl triphenylphosphonium bromide (27 g, 46 mmol), glycolaldehyde (7.2 g; 92 mmol), potassium carbonate (13 g; 92 mmol) and 18-crown-6 (0.2 g) in dichloromethane (300 ml) was stirred for 2 days at ambient temperature under argon atmosphere. After addition of distilled water and extraction, the solution was evaporated to dryness to give methyl 2-(4-fluorophenyl)-4-(3-hydroxyprop-1-en-1-yl)benzoate which was used in the next step without further purification.

1. customthe solution was evaporated to dryness