methyl 4-[(E)-3-(imidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoate → 4-[(E)-3-(imidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoic acid

HRID 1019045Notes

Reaction equation

HRID 1019045 reaction equation
[NH:1]1[C:5]([CH2:6]/[CH:7]=[CH:8]/[C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15]C)=[O:14])=[C:11]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[CH:10]=2)=[CH:4][N:3]=[CH:2]1>Cl>[NH:1]1[C:5]([CH2:6]/[CH:7]=[CH:8]/[C:9]2[CH:18]=[CH:17][C:12]([C:13]([OH:15])=[O:14])=[C:11]([C:19]3[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=3)[CH:10]=2)=[CH:4][N:3]=[CH:2]1

Participants

3

Reactant 1

HCID 18399501methyl 4-[(E)-3-(imidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoate

Product 1

HCID 183995084-[(E)-3-(imidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of methyl 4-[(E)-3-(imidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoate (0.6 g; 1.8 mmol) in 1N HCl (15 ml) was refluxed for 20 hours. The mixture was evaporated to dryness to give 4-[(E)-3-(imidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoic acid as the hydrochloride salt.

Workup

  1. customThe mixture was evaporated to dryness

Sources & evidence

ORD record
ord-0d710f8830004c74bacf13d0f85dc502
Source dataset
uspto-grants-2002_11
Patent number
US06486156B1

Reaction notes

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