Methyl iodide → HCID 18398717, compound

HRID 1019173Notes

Reaction equation

HRID 1019173 reaction equation
[OH:1][C:2]1[N:3]=[C:4]([CH2:7][C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])[S:5][CH:6]=1.CI.[C:18]([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH3:18][O:1][C:2]1[N:3]=[C:4]([CH2:7][C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])[S:5][CH:6]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 2799057HCID 2799057, compound

Product 1

HCID 18398717HCID 18398717, compoundYield 8,014%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a suspension of 2-(4-hydroxy-1,3-thiazol-2-yl)-1-phenylethan-1-one (0.5 g, 2.3 mmol) in acetone (10 mL) at r.t. was added MeI (0.17 mL, 2.7 mmol), followed by K2CO3 (315 mg, 2.3 mmol). After stirring ON at r.t., the solvent was removed and the residue was taken up in Et2O/H2O. The organic layer was dried (MgSO4), filtered, and evaporated to yield o.43 g of the title compound.

Workup

  1. customthe solvent was removed
  2. dry with materialThe organic layer was dried (MgSO4)
  3. filtrationfiltered
  4. customevaporated
  5. customto yield o

Sources & evidence

ORD record
ord-9d497836b4b34f0b940b00b07d0d77e3
Source dataset
uspto-grants-2002_11
Patent number
US06486142B2

Reaction notes

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