反应详情

2.1 g of 4-chloro-5-formyl-2-phenylimidazole (Chem. Pharm. Bull. 1976, 24(5), 960), 3.8 g of 4′-bromomethylbiphenyl-2-sulfonic acid dimethylaminomethylenamide (J. Med. Chem. 1995, 38, 2357) and 2.8 g of K2CO3 were stirred at RT for 30 h in 50 ml of DMF. The reaction mixture was poured onto 500 ml of water and extracted 2 times using 250 ml of EA each time. The organic phase was then washed with 100 ml of water and dried over MgSO4, and the solvent was removed in vacuo. Chromatography on silica gel using MTB yielded 1.9 g of a white, crystalline powder, mp 193° C.

1. extractionextracted 2 times
2. washThe organic phase was then washed with 100 ml of water
3. dry with materialdried over MgSO4
4. customthe solvent was removed in vacuo
5. customChromatography on silica gel using MTB yielded 1.9 g of a white, crystalline powder, mp 193° C.