Anisole → HCID 18400084, compound

HRID 1019258Notes

Reaction equation

HRID 1019258 reaction equation
C([NH:5][S:6]([C:9]1[C:10]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][N:22]3[C:26]([CH:27]=[O:28])=[C:25]([Cl:29])[N:24]=[C:23]3[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[C:17]([Cl:36])[CH:16]=2)=[CH:11][CH:12]=[CH:13][CH:14]=1)(=[O:8])=[O:7])(C)(C)C.C1(OC)C=CC=CC=1>FC(F)(F)C(O)=O>[Cl:36][C:17]1[CH:16]=[C:15]([C:10]2[C:9]([S:6]([NH2:5])(=[O:8])=[O:7])=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:20]=[CH:19][C:18]=1[CH2:21][N:22]1[C:26]([CH:27]=[O:28])=[C:25]([Cl:29])[N:24]=[C:23]1[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

4

Reactant 2

HCID 7519AnisoleHCID 17775489HCID 17775489, compound

Product 1

HCID 18400084HCID 18400084, compoundYield 111.5%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

1.5 g of 3′-chloro-4′-(4-chloro-5-formyl-2-phenylimidazol-1-ylmethyl)-biphenyl-2-sulfonic acid tert-butylamide and 340 μl of anisole are dissolved in 10 ml of trifluoroacetic acid and the solution is stirred at RT for 24 h. The volatile constituents are removed in vacuo, the residue is taken up twice using 50 ml of toluene each time and the volatile constituents are again removed in vacuo. 1.5 g of a colorless foam are obtained.

Workup

  1. customThe volatile constituents are removed in vacuo
  2. customthe volatile constituents are again removed in vacuo

Sources & evidence

ORD record
ord-1183ed022c44415685c5ec4209359cae
Source dataset
uspto-grants-2002_11
Patent number
US06486189B2

Reaction notes

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