m-Chloroperbenzoic acid → HCID 18399125, compound

HRID 1019389Notes

Reaction equation

HRID 1019389 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9](=[O:15])[N:8]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([S:22][CH3:23])[CH:17]=1)[C:7]([C:24]([O:26][CH3:27])=[O:25])=[C:6]2[C:28]1[CH:33]=[C:32]([O:34][CH3:35])[C:31]([O:36][CH3:37])=[C:30]([O:38][CH3:39])[CH:29]=1.ClC1C=CC=C(C(OO)=[O:48])C=1>C(Cl)(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9](=[O:15])[N:8]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([S:22]([CH3:23])=[O:48])[CH:17]=1)[C:7]([C:24]([O:26][CH3:27])=[O:25])=[C:6]2[C:28]1[CH:29]=[C:30]([O:38][CH3:39])[C:31]([O:36][CH3:37])=[C:32]([O:34][CH3:35])[CH:33]=1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 54161899HCID 54161899, compound

Product 1

HCID 18399125HCID 18399125, compoundYield 850.3%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

To a solution of the compound obtained in Example 121 (200 mg) in chloroform (15 ml) is added a solution of m-chloroperbenzoic acid (78 mg) in chloroform (10 ml) at room temperature, and the mixture is stirred for one hour. The reaction mixture is washed with a 5% aqueous sodium hydroxide solution, dried, and concentrated under reduced pressure to give 6,7-dimethoxy-3-methoxycarbonyl-2-(3-methylsulfinylphenyl)-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone (1750 mg) as listed in Table 11.

Workup

  1. washThe reaction mixture is washed with a 5% aqueous sodium hydroxide solution
  2. customdried
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-0b8a3add50f34f1e9f0a4007d0818592
Source dataset
uspto-grants-2002_11
Patent number
US06486155B1

Reaction notes

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