反应详情

A suspension of 3-bromo-5-tert-butylbenzaldehyde (4.17 g, 17.30 mmol), malonic acid (2.15 g, 20.72 mmol) and ammonium acetate (2.66 g, 34.59 mmol) in isopropanol (35 mL) was heated at reflux under nitrogen for 3 h to afford a thick colorless solid. The solid was filtered hot, washed with hot isopropanol (2×25 mL) and dried in vacuo to give the desired racemic product as a colorless solid (2.68 g).

1. temperaturewas heated
2. temperatureat reflux under nitrogen for 3 h
3. customto afford a thick colorless solid
4. filtrationThe solid was filtered hot
5. washwashed with hot isopropanol (2×25 mL)
6. customdried in vacuo