Pyrrolidine → HCID 66907417, compound

HRID 1019545Notes

Reaction equation

HRID 1019545 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[N:23]([CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([F:31])[CH:26]=3)[C:14]3=[N:15][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:17][CH:18]=[C:13]3[CH:12]=2)=[O:10])=[CH:4][CH:3]=1.[NH:32]1[CH2:36][CH2:35][CH2:34][CH2:33]1>>[N:32]1([C:2]2[N:7]=[CH:6][C:5]([NH:8][C:9]([C:11]3[N:23]([CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([F:31])[CH:26]=4)[C:14]4=[N:15][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:17][CH:18]=[C:13]4[CH:12]=3)=[O:10])=[CH:4][CH:3]=2)[CH2:36][CH2:35][CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 86639060N-[6-Chloropyridin-3-yl]-6-trifluoromethyl-1-(3-fluorobenzyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide

Product 1

HCID 66907417HCID 66907417, compoundYield 64.8%

Procedure

According to a method similar to that described in Stage 6.2, by reacting 0.3 g (0.67 mmol) of N-[6-chloropyridin-3-yl]-6-trifluoromethyl-1-(3-fluorobenzyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide, described in the preceding stage, with 0.56 mL (6.68 mmol) of pyrrolidine, we obtain 0.21 g of the expected compound.

Sources & evidence

ORD record
ord-2f7d8f1d1b2e4e69ac7198e16489ac26
Source dataset
uspto-grants-2014_05
Patent number
US08716272B2

Reaction notes

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