反应详情

The crude material from step (a) (165 mmol, ˜47 g) was dissolved in EtOH (700 mL) and treated with 600 mL of 1M NaOH. After stirring overnight, the reaction was acidified with concentrated HCl to pH˜1. The crude reaction was diluted with EtOAc (400 mL) and washed with water. The water was back-extracted with EtOAc. The combined organic extracts were washed with water (2×) and dried over MgSO4. Concentration and evaporation from toluene (2×) gave the sub-title product as a solid.

1. customThe crude reaction
2. washwashed with water
3. extractionThe water was back-extracted with EtOAc
4. washThe combined organic extracts were washed with water (2×)
5. dry with materialdried over MgSO4
6. concentrationConcentration and evaporation from toluene (2×)