Hydrazine hydrate (1:1) → HCID 66660877, compound

HRID 1019685Notes

Reaction equation

HRID 1019685 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([N:14]3[CH2:19][CH2:18][CH:17]([CH2:20][CH2:21][N:22]4C(=O)C5C(=CC=CC=5)C4=O)[CH2:16][CH2:15]3)=[N:12][CH:13]=2)=[CH:4][CH:3]=1.O.NN>C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]([N:14]3[CH2:15][CH2:16][CH:17]([CH2:20][CH2:21][NH2:22])[CH2:18][CH2:19]3)=[N:12][CH:13]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 66660688HCID 66660688, compound

Product 1

HCID 66660877HCID 66660877, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1.3 g (3.03 mmol) of 2-{2-[5′-(4-fluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl]ethyl}-isoindole-1,3-dione, prepared in step 1.3. in 30 mL of ethanol is added slowly at room temperature 0.485 g (15.13 mmol) of hydrazine monohydrate. The reaction mixture is then refluxed for 3 hours.

Workup

  1. temperatureThe reaction mixture is then refluxed for 3 hours

Sources & evidence

ORD record
ord-15586e256b35407f8d767b04dea149d6
Source dataset
uspto-grants-2014_05
Patent number
US08716289B2

Reaction notes

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