反应详情

温度

130 °C

10.37 g (43.80 mmol) of 2,5-dibromopyridine, 10.00 g (43.80 mmol) of tert-butyl 2-piperidin-4-ylethylcarbamate and 6.05 g (43.80 mmol) of potassium carbonate are placed in an autoclave. The mixture is then heated at 130° C. for 12 hours. The reaction mixture is allowed to cool to room temperature and then taken up in chloroform and saturated aqueous sodium hydrogen carbonate solution. The aqueous phase is separated out and extracted twice with chloroform, and the combined organic phases are washed with saturated aqueous sodium chloride solution and dried over sodium sulfate, and the filtrate is concentrated under reduced pressure.

1. temperatureto cool to room temperature
2. customThe aqueous phase is separated out
3. extractionextracted twice with chloroform
4. washthe combined organic phases are washed with saturated aqueous sodium chloride solution
5. dry with materialdried over sodium sulfate
6. concentrationthe filtrate is concentrated under reduced pressure