Hydrochloric Acid → HCID 66661106, compound

HRID 1019709Notes

Reaction equation

HRID 1019709 reaction equation
[CH3:1][NH:2][C:3]([C:5]1[CH:9]=[C:8]([CH2:10][O:11][C:12]([NH:14][CH2:15][CH:16]2[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17]2)=[O:13])[O:7][N:6]=1)=[O:4].[ClH:28]>O1CCOCC1>[ClH:28].[NH:18]1[CH2:19][CH2:20][CH:16]([CH2:15][NH:14][C:12](=[O:13])[O:11][CH2:10][C:8]2[O:7][N:6]=[C:5]([C:3](=[O:4])[NH:2][CH3:1])[CH:9]=2)[CH2:17]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66660979HCID 66660979, compound

Product 1

HCID 66661106HCID 66661106, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The process is performed according to the procedure described in Example 11 (step 11.2.). Starting with 1.30 g (3.40 mmol) of tert-butyl 3-[(3-methylcarbamoylisoxazol-5-ylmethoxycarbonylamino)methyl]pyrrolidine-1-carboxylate and 4.25 mL of hydrogen chloride as a 4N solution in dioxane, and after triturating in diethyl ether, 0.82 g of a white powder is obtained.

Workup

  1. customafter triturating in diethyl ether

Sources & evidence

ORD record
ord-094181da029641039d4516f13cb623f3
Source dataset
uspto-grants-2014_05
Patent number
US08716289B2

Reaction notes

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