HCID 67467810, compound → HCID 67468959, compound

HRID 1019726Notes

Reaction equation

HRID 1019726 reaction equation
[C:1]([O:5][C:6](=[O:26])[N:7]([CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2]>C1COCC1>[C:1]([O:5][C:6](=[O:26])[N:7]([CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=1)[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 67467810HCID 67467810, compound

Product 1

HCID 67468959HCID 67468959, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Benzyl-[2-(4-nitro-phenyl)-ethyl]-carbamic acid tert-butyl ester (100 mmol) was dissolved in THF (20 ml) and hydrogenated under a pressure of one atmosphere overnight. The reaction mixture was filtered and washed with THF. The filtrate was concentrated to dryness and was used directly in the procedure for Example 1D.

Workup

  1. filtrationThe reaction mixture was filtered
  2. washwashed with THF
  3. concentrationThe filtrate was concentrated to dryness

Sources & evidence

ORD record
ord-6dff9948bda044958b3526fbc702b2be
Source dataset
uspto-grants-2014_05
Patent number
US08716287B2

Reaction notes

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