Hydrochloric Acid → HCID 54596820, compound

HRID 1019728Notes

Reaction equation

HRID 1019728 reaction equation
C(OC(=O)[N:7]([CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17]([NH:19][C:20]2[CH:25]=[N:24][C:23]([C:26]#[N:27])=[CH:22][N:21]=2)=[O:18])=[CH:12][CH:11]=1)(C)(C)C.Cl>O1CCOCC1>[CH2:28]([NH:7][CH2:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([NH:16][C:17]([NH:19][C:20]2[CH:25]=[N:24][C:23]([C:26]#[N:27])=[CH:22][N:21]=2)=[O:18])=[CH:14][CH:15]=1)[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67465943HCID 67465943, compound

Product 1

HCID 54596820HCID 54596820, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Benzyl-(2-{4-[3-(5-cyano-pyrazin-2-yl)-ureido]-phenyl}-ethyl)-carbamic acid tert-butyl ester (1 mmol) was treated with 4N HCl in dioxane (10 ml) and stirred overnight at room temperature. The product was precipitated by addition of dry ether. The crude was purified by column using 0-100% 7 N NH3/MeOH in DCM to afford the title compound as a free base.

Workup

  1. customThe product was precipitated by addition of dry ether
  2. customThe crude was purified by column

Sources & evidence

ORD record
ord-5da4af5333354a3fa43df1108a835d62
Source dataset
uspto-grants-2014_05
Patent number
US08716287B2

Reaction notes

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