反应详情

4-Chloro-N-methylbutane-1-sulfonamide (54 mmol), KCN (108 mmol) and 18-crown ether-6 (11 mmol) were dissolved in CH3CN (100 ml). The mixture was stirred at reflux temperature overnight. The mixture was cooled and filtered. The residue was purified by flash column chromatography over silica gel (eluent: CH2Cl2, then ethyl acetate). Yield: 3.2 g (70% purity).

1. temperatureat reflux temperature overnight
2. temperatureThe mixture was cooled
3. filtrationfiltered
4. customThe residue was purified by flash column chromatography over silica gel (eluent