Potassium Cyanide → HCID 71699857, compound

HRID 1019840Notes

Reaction equation

HRID 1019840 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][S:6]([NH:9][CH3:10])(=[O:8])=[O:7].[C-:11]#[N:12].[K+]>CC#N>[C:11]([CH2:2][CH2:3][CH2:4][CH2:5][S:6]([NH:9][CH3:10])(=[O:8])=[O:7])#[N:12]

Participants

4

Reactant 2

HCID 9032Potassium CyanideHCID 103751644-chloro-N-methylbutane-1-sulfonamide

Product 1

HCID 71699857HCID 71699857, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

4-Chloro-N-methylbutane-1-sulfonamide (54 mmol), KCN (108 mmol) and 18-crown ether-6 (11 mmol) were dissolved in CH3CN (100 ml). The mixture was stirred at reflux temperature overnight. The mixture was cooled and filtered. The residue was purified by flash column chromatography over silica gel (eluent: CH2Cl2, then ethyl acetate). Yield: 3.2 g (70% purity).

Workup

  1. temperatureat reflux temperature overnight
  2. temperatureThe mixture was cooled
  3. filtrationfiltered
  4. customThe residue was purified by flash column chromatography over silica gel (eluent

Sources & evidence

ORD record
ord-65ee3938be8f4713a3559e2edf75039d
Source dataset
uspto-grants-2014_05
Patent number
US08716293B2

Reaction notes

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