Hydrochloric Acid → 3-Amino-2-(thiophen-3-yl)propanoic acid

HRID 1020146Notes

Reaction equation

HRID 1020146 reaction equation
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[CH2:12][CH:13]([C:18]1[CH:22]=[CH:21][S:20][CH:19]=1)[C:14]([O:16]C)=[O:15].Cl>>[NH2:3][CH2:12][CH:13]([C:18]1[CH:22]=[CH:21][S:20][CH:19]=1)[C:14]([OH:16])=[O:15]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 59161752Methyl 3-(1,3-dioxoisoindolin-2-yl)-2-(thiophen-3-yl)propanoate

Product 1

HCID 197566333-Amino-2-(thiophen-3-yl)propanoic acid

Procedure

To methyl 3-(1,3-dioxoisoindolin-2-yl)-2-(thiophen-3-yl)propanoate (E429) was added 6 N HCl and the solution was refluxed for 4 h. The solvents were evaporated to give 3-amino-2-(thiophen-3-yl)propanoic acid (E430).

Workup

  1. temperaturethe solution was refluxed for 4 h
  2. customThe solvents were evaporated

Sources & evidence

ORD record
ord-1adcd1f7fd1c4a55bb28d3ade82fe2d5
Source dataset
uspto-grants-2014_05
Patent number
US08716310B2

Reaction notes

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