Hydrochloric Acid → HCID 86622755, compound

HRID 1020258Notes

Reaction equation

HRID 1020258 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][N:10]([CH2:12][C:13]1[N:14]=[C:15]([NH:18][C:19]([NH:21][CH2:22][C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[C:25]([Cl:30])[CH:24]=2)=[O:20])[S:16][CH:17]=1)[CH3:11])(C)(C)C.Cl>O1CCOCC1>[ClH:29].[NH2:7][CH2:8][CH2:9][N:10]([CH2:12][C:13]1[N:14]=[C:15]([NH:18][C:19]([NH:21][CH2:22][C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[C:25]([Cl:30])[CH:24]=2)=[O:20])[S:16][CH:17]=1)[CH3:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86622756HCID 86622756, compound

Product 1

HCID 86622755HCID 86622755, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

[2-({2-[3-(3,4-Dichloro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amino)-ethyl]-carbamic acid tert-butyl ester (Example 102) was treated with HCl, 4.0M in dioxane in a similar way as Example 78 to give the title compound. 1H NMR (400 MHz, CD3OD): 7.50-7.44 (m, 2H), 7.28-7.24 (m, 2H), 4.41 (s, 4H), 3.46 (br s, 4H), 2.95 (s, 3H). MS (ES+): M/Z 388, 390 (M+1).

Sources & evidence

ORD record
ord-0e9eb6e9c228407ebbf684b0d7fe8337
Source dataset
uspto-grants-2014_05
Patent number
US08716320B2

Reaction notes

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