Benzyl Bromide → 8-(5-Aminopyridin-2-yl)-2-benzyl-2,8-diazaspiro[4,5]decan-1-one

HRID 1020353Notes

Reaction equation

HRID 1020353 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][N:3]=1.[C:11]1(=[O:21])[C:15]2([CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[CH2:14][CH2:13][NH:12]1.[CH2:22](Br)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[NH2:8][C:5]1[CH:6]=[CH:7][C:2]([N:18]2[CH2:19][CH2:20][C:15]3([C:11](=[O:21])[N:12]([CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH2:13][CH2:14]3)[CH2:16][CH2:17]2)=[N:3][CH:4]=1

Participants

4

Reactant 3

HCID 7498Benzyl BromideHCID 783082-Chloro-5-nitropyridineHCID 222250112,8-Diazaspiro[4.5]decan-1-one

Product 1

HCID 584289928-(5-Aminopyridin-2-yl)-2-benzyl-2,8-diazaspiro[4,5]decan-1-one

Procedure

Intermediate B-17 was prepared by the general procedure for intermediate B-15, by using 2-chloro-5-nitropyridine, 2,8-diazaspiro[4,5]decan-1-one, and benzyl bromide as starting materials. MS (M+1): 337.3

Sources & evidence

ORD record
ord-63865aceddee4b35b852a71e6b34a1fc
Source dataset
uspto-grants-2014_05
Patent number
US08716312B2

Reaction notes

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