反应详情

To a cooled (4° C.) solution of PhMe2P (71 mg; 0.52 mmol) in dichloromethane (1 mL) was added dropwise during 1 min DIAD (104 mg; 0.52 mmol). After additional 5 min of stirring a solution of alcohol 12 (84 mg; 0.24 mmol) and Et3N (7 μL; 0.05 mmol) in dichloromethane (1 mL) was added dropwise. After 10 min the reaction mixture was directly loaded on a silica column. Chromatography [hexane-ethyl acetate (3:1)→(2:1), 6 ml silica] afforded 53 mg (70%) of aziridine 13 as a colourless oil with trace amounts of 14.

1. additionwas added dropwise