Lithium hydroxide, monohydrate → HCID 66689518, compound

HRID 1020437Notes

Reaction equation

HRID 1020437 reaction equation
[CH3:1][C:2]1[C:19]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([NH:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]([O:14]C)=[O:13])=[O:5].O.[OH-].[Li+]>C1COCC1.O>[CH3:1][C:2]1[C:19]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([NH:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[O:5]

Participants

4

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 66689417HCID 66689417, compound

Product 1

HCID 66689518HCID 66689518, compoundYield 90.5%

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

The procedure of the step 2 in Example 80 was repeated except that the methyl 6-(2-methyl-3-phenyl-benzamido)hexanoate (61 mg, 0.18 mmol) instead of methyl 6-(3-bromo-2-methylbenzamido)hexanoate, and 15 mg of lithium hydroxide monohydrate (0.36 mmol) were dissolved in 3 mL of THF/H2O (2:1) to obtain the title compound (53 mg, 90%).

Sources & evidence

ORD record
ord-e55ae888a0624050a21c9093c4134e82
Source dataset
uspto-grants-2014_05
Patent number
US08716326B2

Reaction notes

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