Lithium hydroxide, monohydrate → HCID 66689595, compound

HRID 1020440Notes

Reaction equation

HRID 1020440 reaction equation
[CH3:1][C:2]1[C:19]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][C:21]=2[O:28][CH3:29])=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([NH:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]([O:14]C)=[O:13])=[O:5].O.[OH-].[Li+]>C1COCC1.O>[CH3:1][C:2]1[C:19]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][C:21]=2[O:28][CH3:29])=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([NH:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[O:5]

Participants

4

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 66690111HCID 66690111, compound

Product 1

HCID 66689595HCID 66689595, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

The procedure of the step 2 in Example 92 was repeated except that methyl 6-(2-methyl-3-(2,4-dimethoxyphenyl)-benzamido)hexanoate (30 mg, 0.075 mmol) and lithium hydroxide monohydrate (6 mg, 0.15 mmol) were dissolved in 3 mL of THF/H2O (2:1) to obtain the title compound (27 mg, 94%).

Sources & evidence

ORD record
ord-2fe60cd07d2d48ea91ac4d6748de2d74
Source dataset
uspto-grants-2014_05
Patent number
US08716326B2

Reaction notes

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