Hydroxyamine hydrochloride → HCID 49805675, compound

HRID 1020441Notes

Reaction equation

HRID 1020441 reaction equation
[CH3:1][C:2]1[C:18]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:20]=2[O:27][CH3:28])=[CH:17][CH:16]=[CH:15][C:3]=1[C:4]([NH:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12](O)=[O:13])=[O:5].Cl.[NH2:30][OH:31]>>[OH:31][NH:30][C:12]([CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][NH:6][C:4](=[O:5])[C:3]1[CH:15]=[CH:16][CH:17]=[C:18]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:20]=2[O:27][CH3:28])[C:2]=1[CH3:1])=[O:13]

Participants

3

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 66689595HCID 66689595, compound

Product 1

HCID 49805675HCID 49805675, compoundYield 35%

Procedure

The procedure of the step 3 in Example 80 was repeated except that 6-(2-methyl-3-(2,4-dimethoxyphenyl)-benzamido)hexanoic acid instead of 6-(3-bromo-2-methylbenzamido)hexanoic acid, and hydroxylamine hydrochloride instead of 1,2-phenylenediamine were used and purified by a preparative HPLC (C18, 20% H2O/CH3CN, 20 ml/min) to obtain the title compound (27 mg, 35%).

Workup

  1. custompurified by a preparative HPLC (C18, 20% H2O/CH3CN, 20 ml/min)

Sources & evidence

ORD record
ord-b3ee56b7ebfb4cb781c992c04afc506a
Source dataset
uspto-grants-2014_05
Patent number
US08716326B2

Reaction notes

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