Hydrochloric Acid → HCID 68656833, compound

HRID 1020688Notes

Reaction equation

HRID 1020688 reaction equation
[ClH:1].CCOCC.[CH3:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][N:18]([C:21]3[CH:22]=[CH:23][C:24]4[C:25]5[CH2:34][NH:33][CH2:32][CH2:31][C:26]=5[N:27]([CH3:30])[C:28]=4[CH:29]=3)[C:17](=[O:35])[CH:16]=2)=[CH:11][CH:10]=1>C(Cl)Cl>[ClH:1].[CH3:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][N:18]([C:21]3[CH:22]=[CH:23][C:24]4[C:25]5[CH2:34][NH:33][CH2:32][CH2:31][C:26]=5[N:27]([CH3:30])[C:28]=4[CH:29]=3)[C:17](=[O:35])[CH:16]=2)=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 50908738HCID 50908738, compound

Product 1

HCID 68656833HCID 68656833, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2 N HCl in Et2O (0.12 mL, 0.24 mmol) was added to a solution of 4-(4-methoxyphenyl)-1-(5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)pyridin-2(1H)-one (45 mg, 0.12 mmol) in CH2Cl2 (2.0 mL), and the solution was stirred at ambient temperature for 2.5 h under N2. The reaction mixture was concentrated, partially diluted with H2O and lyophilized to provide the title compound (46 mg, 95%) as a yellow powder:

Workup

  1. concentrationThe reaction mixture was concentrated
  2. additionpartially diluted with H2O

Sources & evidence

ORD record
ord-3c90fee0239f48fba87ab2c96bcde3c9
Source dataset
uspto-grants-2014_05
Patent number
US08716308B2

Reaction notes

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