Hydrochloric Acid → HCID 66797470, compound

HRID 1020731Notes

Reaction equation

HRID 1020731 reaction equation
C(OC([N:8]1[CH:12]=[C:11]([C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[N:19]=[C:18]([N:23]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH3:24])[CH:17]=[N:16]3)[CH:10]=[N:9]1)=O)(C)(C)C.[ClH:32]>O1CCOCC1>[ClH:32].[CH2:25]([N:23]([CH3:24])[C:18]1[CH:17]=[N:16][C:15]2[C:20](=[CH:21][CH:22]=[C:13]([C:11]3[CH:10]=[N:9][NH:8][CH:12]=3)[CH:14]=2)[N:19]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66797397HCID 66797397, compound

Product 1

HCID 66797470HCID 66797470, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To an ice cold solution of 4-[2-(Benzyl-methyl-amino)-quinoxalin-6-yl]-pyrazole-1-carboxylic acid tert-butyl ester (250 mg) in 1,4-dioxane (3 mL), HCl (in 1,4-dioxane) was added. The resulting mixture was allowed to warm to RT and was stirred further for 2 hours. After completion of the reaction the volatiles were evaporated under vacuum and the HCl salt of the final compound was triturated with DCM. The product was further purified by preparative HPLC (0.009 g, 3%).

Workup

  1. customAfter completion of the reaction the volatiles
  2. customwere evaporated under vacuum
  3. customthe HCl salt of the final compound was triturated with DCM
  4. customThe product was further purified by preparative HPLC (0.009 g, 3%)

Sources & evidence

ORD record
ord-be2006e66a244df5affff12a7c24e5fe
Source dataset
uspto-grants-2014_05
Patent number
US08716473B2

Reaction notes

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