反应详情

To solution of 6-bromo-2-chloro-quinoxaline (0.7 g, 1 eq, 2.87 mmol) in THF (6 mL) was added a solution of methyl amine in THF (3 mL) at room temperature. The mixture was stirred at room temperature for 2 h. After completion of the reaction, the volatiles were removed under vacuum and water (20 mL) was added to reaction mixture. The aqueous layer was extracted with ethyl acetate (15 mL×3). The organic layer was washed with water (20 mL) and brine (20 mL) and then dried over Na2SO4. The organic layer was concentrated under vacuum to afford the crude product.

1. customAfter completion of the reaction
2. customthe volatiles were removed under vacuum and water (20 mL)
3. additionwas added to reaction mixture
4. extractionThe aqueous layer was extracted with ethyl acetate (15 mL×3)
5. washThe organic layer was washed with water (20 mL) and brine (20 mL)
6. dry with materialdried over Na2SO4
7. concentrationThe organic layer was concentrated under vacuum