Hydrochloric Acid → HCID 66797181, compound

HRID 1020757Notes

Reaction equation

HRID 1020757 reaction equation
C(OC([N:8]1[CH:12]=[C:11]([C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[N:19]=[C:18]([NH:23][C@@H:24]([C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([Cl:32])[CH:27]=2)[CH3:25])[CH:17]=[N:16]3)[CH:10]=[N:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[ClH:32].[Cl:32][C:28]1[CH:27]=[C:26]([C@H:24]([NH:23][C:18]2[CH:17]=[N:16][C:15]3[C:20](=[CH:21][CH:22]=[C:13]([C:11]4[CH:10]=[N:9][NH:8][CH:12]=4)[CH:14]=3)[N:19]=2)[CH3:25])[CH:31]=[CH:30][CH:29]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66797158HCID 66797158, compound

Product 1

HCID 66797181HCID 66797181, compoundYield 39.6%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To an ice cold solution of 4-{2-[(R)-1-(3-Chloro-phenyl)-ethylamino]-quinoxalin-6-yl}-pyrazole-1-carboxylic acid tert-butyl ester (0.1 g,) in 1,4-dioxane (3 mL) was added 14% HCl in dioxane (2 mL). The resulting mixture was stirred at RT for 2 hours. After completion of the reaction, the volatiles were evaporated off completely and the solid was triturated with acetone to afford the title compound as the HCl salt (0.017 g, 20%).

Workup

  1. customAfter completion of the reaction
  2. customthe volatiles were evaporated off completely
  3. customthe solid was triturated with acetone

Sources & evidence

ORD record
ord-5fa2efe68d304ad0bb1c2ba0be55d2ab
Source dataset
uspto-grants-2014_05
Patent number
US08716473B2

Reaction notes

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