反应详情

温度

150 °C

To a solution of intermediate compound D2 (1.2 g, 4.15 mmol) in THF (12 ml), was added hydrazine monohydrate (0.416 g, 8.301 mmol). The reaction mixture was subjected to microwave heating at 150° C. for 1 min. After cooling, additional hydrazine monohydrate (1 eq) was added to the resulting mixture, which was then subjected to microwave heating at 150° C. for 0.5 min. After cooling, the reaction mixture was concentrated in vacuo. The residue thus obtained was triturated with Et2O to yield intermediate compound D3 (0.95 g, 95%).

1. temperatureAfter cooling
2. temperatureto microwave heating at 150° C. for 0.5 min
3. temperatureAfter cooling
4. concentrationthe reaction mixture was concentrated in vacuo
5. customThe residue thus obtained
6. customwas triturated with Et2O