Benzyl Bromide → HCID 86686198, compound

HRID 1021222Notes

Reaction equation

HRID 1021222 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[CH2:3][CH2:2]1.[CH2:15]([Br:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C1COCC1>[Br-:22].[CH2:15]([N+:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][CH:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)=[CH:10][CH:11]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 7498Benzyl BromideHCID 68309841HCID 68309841, compound

Product 1

HCID 86686198HCID 86686198, compoundYield 91.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4-(Tetrahydro-2H-pyran-4-ylmethoxy)pyridine (1.1 g) was mixed with THF (12 ml), and benzyl bromide (1.4 g) was added thereto, followed by stirring at room temperature overnight. The precipitated solid was collected by filtration to obtain 1-benzyl-4-(tetrahydro-2H-pyran-4-ylmethoxy)pyridinium bromide (1.9 g).

Workup

  1. additionwas added
  2. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-2f98a0b2359f45ac98636224292bc2ad
Source dataset
uspto-grants-2014_05
Patent number
US08716470B2

Reaction notes

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