反应详情

[3-({[tert-Butyl(dimethyl)silyl]oxy}methyl)phenyl][2-(morpholin-4-yl)pyrimidin-5-yl]methanol (400 mg), triethylsilane (364 mg), and TFA (4 ml) were mixed, followed by stirring at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and EtOAc and water were added to the obtained residue. The organic layer was dried over MgSO4 and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain (3-{[2-(morpholin-4-yl)pyrimidin-5-yl]methyl}phenyl)methanol (39 mg).

1. concentrationThe reaction mixture was concentrated under reduced pressure, and EtOAc and water
2. additionwere added to the obtained residue
3. dry with materialThe organic layer was dried over MgSO4
4. concentrationconcentrated under reduced pressure
5. customThe obtained residue was purified by silica gel column chromatography