Hydrochloric Acid → HCID 86684442, compound

HRID 1022019Notes

Reaction equation

HRID 1022019 reaction equation
[C:1]([O:4][CH2:5][C:6]1[C:7]([N:37]2[CH2:48][CH2:47][N:46]3[C:39](=[CH:40][C:41]4[CH2:42][C:43]([CH3:50])([CH3:49])[CH2:44][C:45]=43)[C:38]2=[O:51])=[N:8][CH:9]=[CH:10][C:11]=1[C:12]1[CH:13]=[C:14]([NH:20][C:21]2[S:22][C:23]3[CH2:24][N:25](C(OC(C)(C)C)=O)[CH2:26][CH2:27][C:28]=3[N:29]=2)[C:15](=[O:19])[N:16]([CH3:18])[CH:17]=1)(=[O:3])[CH3:2].Cl>C(OCC)(=O)C>[C:1]([O:4][CH2:5][C:6]1[C:7]([N:37]2[CH2:48][CH2:47][N:46]3[C:39](=[CH:40][C:41]4[CH2:42][C:43]([CH3:50])([CH3:49])[CH2:44][C:45]=43)[C:38]2=[O:51])=[N:8][CH:9]=[CH:10][C:11]=1[C:12]1[CH:13]=[C:14]([NH:20][C:21]2[S:22][C:23]3[CH2:24][NH:25][CH2:26][CH2:27][C:28]=3[N:29]=2)[C:15](=[O:19])[N:16]([CH3:18])[CH:17]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86684441HCID 86684441, compound

Product 1

HCID 86684442HCID 86684442, compoundYield 95.2%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of 233b (220 mg, 0.308 mmol) in ethyl acetate (5 mL) was added a solution of HCl in ethyl acetate (0.123 mL, 2.5M, 0.308 mmol). The mixture was stirred at room temperature for 1 h. It was then concentrated under reduced pressure to afford 233c (180 mg, crude), which was used directly for next step without further purification. MS-ESI: [M+H]+ 614.3

Workup

  1. concentrationIt was then concentrated under reduced pressure

Sources & evidence

ORD record
ord-8e5521050ab04eb698cfd8ef8e534427
Source dataset
uspto-grants-2014_05
Patent number
US08716274B2

Reaction notes

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