反应详情

温度

95 °C

To 1.24 g of 8-chloro-4-phenyl-2(1H)-quinazolinone (compound No. IV-4) was added 6.65 g of phosphorus oxychloride, followed by stirring at 95° C. for 1 hour. The resulting reaction solution was poured into 200 ml of ice water and sodium bicarbonate was added thereto, thereby adjusting the pH 9. Then, precipitated crystals were collected by filtration and recrystallized from ethanol to obtain 1.07 g of the titled compound. Mp.154.4.° C. 1H NMR (CDCl3): 7.52-7.65 (4H, m), 7.76-7.80 (2H, m), 8.02-8.08 (2H, m).

1. customThe resulting reaction solution
2. additionwas added
3. customThen, precipitated crystals
4. filtrationwere collected by filtration
5. customrecrystallized from ethanol