反应详情

To a solution of 5-[9-(2,5-Dioxo-pyrrolidin-1-yloxycarbonyl)-nonyloxy]-isophthalic acid di-tert-butyl ester (62 mg, 0.11 mmol) in dry DMF (1 ml), H-Glu-OtBu (0.027 g, 0.13 mmol) and DIPEA (0.05 ml) was added. The mixture was stirred over night under nitrogen for 4 h. The mixture was concentrated. The residue was redissolved in EtOAc and washed with 0.1 N HCl (2×), brine (1×), dried (Na2SO4) and concentrated to give a syrup.

1. concentrationThe mixture was concentrated
2. dissolutionThe residue was redissolved in EtOAc
3. washwashed with 0.1 N HCl (2×), brine (1×)
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated
6. customto give a syrup