反应详情

A mixture of 0.1 g of 6-acetyl-3-(3,4-dimethoxybenzyl)-1-(tetrahydro-2H-pyran-4-yl)-quinazoline-2,4(1H,3H)-dione, 0.057 g of potassium iodide, 0.01 g of lithium chloride, 0.019 g of gallium and 0.065 g of trimethylsilylpropargyl bromide in 1 ml of THF is refluxed for 2 hours and then left for 2 days at room temperature. The reaction mixture is filtered through Celite and evaporated under reduced pressure. The residue is chromatographed on silica gel, eluting with a DCM/EtOAc mixture from (70/30, v/v) to give 0.112 g of the expected product.

1. temperatureis refluxed for 2 hours
2. filtrationThe reaction mixture is filtered through Celite
3. customevaporated under reduced pressure
4. customThe residue is chromatographed on silica gel
5. washeluting with a DCM/EtOAc mixture from (70/30, v/v)