Hydrochloric Acid → HCID 59625999, compound

HRID 1023054Notes

Reaction equation

HRID 1023054 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:16][CH2:15][C:14]2[C:9](=[C:10]([C:17]([O:19]C)=[O:18])[CH:11]=[CH:12][CH:13]=2)[CH2:8]1.[OH-].[Na+].Cl>C1COCC1>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:16][CH2:15][C:14]2[C:9](=[C:10]([C:17]([OH:19])=[O:18])[CH:11]=[CH:12][CH:13]=2)[CH2:8]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59625970HCID 59625970, compound

Product 1

HCID 59625999HCID 59625999, compoundYield 311.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compound 9u (187 mg, 0.44 mmol) was refluxed with 3N aqueous NaOH (0.25 mL mg, 0.75 mmol) in THF (6 mL) overnight. Concentrated HCl solution was added to the mixture to adjust pH to 3-4. The resulting mixture was concentrated to give 9v (350 mg) as the tris-HCl salt.

Workup

  1. concentrationThe resulting mixture was concentrated

Sources & evidence

ORD record
ord-dbeb26e2d1f5405ba882860c027f86a6
Source dataset
uspto-grants-2014_05
Patent number
US08722658B2

Reaction notes

Loading…