Hydroxyamine hydrochloride → HCID 86762396, compound

HRID 1023413Notes

Reaction equation

HRID 1023413 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([CH2:10][OH:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].Cl.[NH2:13][OH:14]>CO>[F:1][C:2]1[CH:9]=[C:8]([CH2:10][OH:11])[CH:7]=[CH:6][C:3]=1[C:4](=[N:13][OH:14])[NH2:5]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 118296312-Fluoro-4-(hydroxymethyl)benzonitrile

Product 1

HCID 86762396HCID 86762396, compoundYield 42.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of 2-fluoro-4-hydroxymethylbenzonitrile (CAS 222978-02-1) (2.5 g, 16.5 mmol) in methanol (30 mL) was added hydroxylamine hydrochloride (3 mL, 50 mmol). After heating to 50° C. with stirring for 16 h, the reaction mixture was cooled to RT and concentrated to afford 1.3 g of Intermediate 5.

Workup

  1. temperaturethe reaction mixture was cooled to RT
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-9e91cc4724e745ac9f4a7c9e0bdce709
Source dataset
uspto-grants-2014_05
Patent number
US08722712B2

Reaction notes

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